Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

The thirteenth century mystic Ibn ʻArabi was the foremost Sufi theorist of the premodern era. For more than a century, Western scholars and esotericists have heralded his universalism, arguing that he saw all contemporaneous religions as equally valid. In Rethinking Ibn ʻArabi, Gregory Lipton calls this image into question and throws into relief how Ibn ʻArabi's discourse is inseparably intertwined with the absolutist vision of his own religious milieu-- that is, the triumphant claim that Islam fulfilled, superseded, and therefore (...) abrogated all previous revealed religions. Lipton juxtaposes Ibn ʻArabi's absolutist conception with the later reception of his ideas, exploring how they have been read, appropriated, and universalized within the reigning interpretive field of Perennial Philosophy in the study of Sufism. The contours that surface through this comparative analysis trace the discursive practices that inform Ibn ʻArabi's Western reception back to the eighteenth and nineteenth century study of 'authentic' religion, where European ethno-racial superiority was wielded against the Semitic Other - both Jewish and Muslim. Lipton argues that supersessionist models of exclusivism are buried under contemporary Western constructions of religious authenticity in ways that ironically mirror Ibn ʻArabi's medieval absolutism. (shrink)

SUMMARYSchleiermacher's doctrine of the Trinity is constituted not only by his Glaubenslehre but also in Über den Gegensatz zwischen der Sabellianischen und der Athanasianischen Vorstellung von der Trinität . Schleiermacher can be seen to construe the persons of the Trinity as the circumscription of divinity. This point leads to consideration of divine wisdom as the ground of both the immanent and economic Trinity.

What makes any investigative field a scientific discipline? This article argues that disciplines are ever-changing frameworks within which scientific activity is organised. Moreover, disciplinarity is not a yes or no proposition: scientific activities may achieve degrees of identity development. Degree of consensus is the key, and consensus on many questions (conceptual, methodological, institutional, and social) varies among sciences. Lastly, disciplinary development is non-teleological. Disciplines pass through no regular stages on their way from immature to mature status, designations articulated within the (...) rhetoric of discipline formation. Scientists assemble disciplines using many elements: phenomena, methods, instruments, theories, analytical techniques, and institutional tools such as journals, government bureaus, and university positions. Scientists created geophysics during the nineteenth and twentieth centuries through such a combination. Whether geophysics became a discipline depends on how discipline is defined. (shrink)

This book joins a small number of efforts in the last decade to present the complex scientific issues of geomagnetism to a broader, semi-technical audience. The author approaches this goal more closely than most scientists and science writers. He specifically eschews mathematical equations knowing that even one equation leads some readers to give up trying. He offers instead a mix of description and story-telling, the former directed at phenomena and procedures, the latter drawn mostly from personal experience.As Merrill notes, his (...) wife insisted that he “explain the material in a way she could understand it” (vii). A virtue of this is an enforced candor often obscured by mathematics, even in semi-popular accounts. This is most clear in addressing fundamental questions, such as when he asks what produces the magnetic field of magnets. In a paragraph that begins with a simple bar magnet, the author successively halves the magnet until he has only an electron remaining. This he calls a po. (shrink)

Vocal affect is a subcomponent of emotion programs that coordinate a variety of physiological and psychological systems. Emotional vocalizations comprise a suite of vocal behaviors shaped by evolution to solve adaptive social communication problems. The acoustic forms of vocal emotions are often explicable with reference to the communicative functions they serve. An adaptationist approach to vocal emotions requires that we distinguish between evolved signals and byproduct cues, and understand vocal affect as a collection of multiple strategic communicative systems subject to (...) the evolutionary dynamics described by signaling theory. We should expect variability across disparate societies in vocal emotion according to culturally evolved pragmatic rules, and universals in vocal production and perception to the extent that form–function relationships are present. (shrink)

The usual problems of measurement and its meaning are complicated and magnified when the object of study is in principle and in fact inaccessible. When a phenomenon occurs in a place where our instruments cannot reach, what can the relation between the instrument, its reading, and the phenomenon be? This essay asks how researchers have addressed questions about inaccessible processes of Earth's magnetic field on the surface, at the edge of space and under its surface. This case takes us beyond (...) simple contrasts of inductive and deductive methods, or field sciences versus basic sciences, to a messier, more nuanced view of inherently complex sciences. The article focuses on investigations of Earth's magnetism and electricity, but its perspectives are applicable to many areas of recent science. (shrink)

Verbal irony constitutes a rough class of indirect intentional communication involving a complex interaction of language-specific and communication-general phenomena. Conversationalists use verbal irony in conjunction with paralinguistic signals such as speech prosody. Researchers examining acoustic features of speech communication usually focus on how prosodic information relates to the surface structure of utterances, and often ignore prosodic phenomena associated with implied meaning. In the case of verbal irony, there exists some debate concerning how these prosodic features manifest themselves in conversation. A (...) form-function approach can provide a valuable tool for understanding speakers' varied vocal strategies in this domain. Here I describe several ways conversationalists employ prosodic contrasts, laughter, and other speech characteristics in their attempts to communicate effectively and efficiently. The presented examples, culled from spontaneous conversation recordings, reveal just a small sample of the enormous variation in delivery styles speakers adopt when communicating with ironic language. (shrink)

Schizophrenia patients exhibit impairments across multiple clinical, cognitive, and functional domains. A fundamental abnormality of the timing and/or efficiency of neural processes across disparate brain regions (i.e., cortico-cortical communications) may underlie many of the deficits in schizophrenia. Because gamma synchrony is temporally correlated with many cognitive processes, probing patterns of gamma activation may shed light on the functional integrity of neural circuits in schizophrenia and related disorders.

We explored the differential impact of auditory information and written contextual information on the recognition of verbal irony in spontaneous speech. Based on relevance theory, we predicted that speakers would provide acoustic disambiguation cues when speaking in situations that lack other sources of information, such as a visual channel. We further predicted that listeners would use this information, in addition to context, when interpreting the utterances. People were presented with spontaneously produced ironic and nonironic utterances from radio talk shows in (...) written or auditory form, with or without written contextual information. When the utterances were read without written contextual information, all utterances were rated as equally ironic. But when they were heard as opposed to read, or when they were presented in irony-biasing contexts, originally ironic utterances were rated as more sarcastic than originally nonironic utterances. This evidence suggests both acoustic and contextual information are used when inferring ironic intent in spontaneous speech, and validates previous manipulations of intonation in studies of irony understanding. (shrink)

This paper examines the status of naturalism in the philosophies of Edmund Husserl and John Dewey. Despite the many points of overlap and agreement between Husserl’s and Dewey’s philosophical projects, there remains one glaring difference, namely, the place and status of naturalism in their approaches. For Husserl, naturalism is an enemy to be vanquished. For Dewey, naturalism is the only method that can put philosophy back in touch with the concerns of human beings. This paper will demonstrate the remarkable similarities (...) between Husserl’s and Dewey’s thought before contending that Dewey’s “naturalistic humanism” offers a conception of naturalism which is compatible with Husserlian phenomenology. Furthermore, reading these two philosophers together, this paper argues, can point the way forward to a naturalism which avoids the dismissal of the contributions made by knowing subjects carried out by dominant contemporary strains of reductive naturalism. (shrink)

Sumantra Ghoshal’s condemnation of “bad management theories” that were “destroying good management practices” has not lost any of its salience, after a decade. Management theories anchored in agency theory (and neo-classical economics generally) continue to abet the financialization of society and undermine the functioning of business. An alternative approach (drawn from a more classic institutional, new ecological, and refocused ethical approaches) is reviewed.

Throughout his career, Jean-Paul Sartre had a contentious theoretical relationship with psychoanalysis. Nowhere is this more evident than in his criticisms of the concept of the unconscious. For him, the unconscious represents a hidden psychological depth that is anathema to the notion of human freedom. In this paper, I argue that Lacan’s conception of the unconscious-structured-like-a-language overcomes many of Sartre’s most damning objections. I demonstrate that Lacan shares with Sartre a concern to rid the psyche of hidden depths. Both thinkers (...) therefore reject the depth psychological conception of the unconscious and arrive at strikingly similar positions on the nature of the unconscious. In this way, I show that the conceptual analogues that Sartre develops in order to avoid the psychoanalytic unconscious lead him to a position on the unconscious with which Lacan could be in agreement. This indicates that Sartre’s philosophical position is not as at odds with Freudian-Lacanian psychoanalysis as is typically thought. (shrink)

A major aim of the books in this series is to promote psychology's appreciation of the neglected giants in its history. The chapters document the significance of these early contributions, many of them made more than a century ago. Most of the chapters are revisions of invited addresses delivered at psychological conventions. Several of the authors are students, colleagues, or offspring of their pioneers and all of them are intrigued by the life and work of the psychologists about whom they (...) have written. All of the portraits are informal; on occasion, even humorous. Some are "impersonations"--telling stories in what were or might have been the pioneer's own words. This book provides source materials for teachers of undergraduate courses in psychology--particularly the history of psychology--who want to add a personal view in their lectures and offer interesting readings for their students. Each of the five volumes in this series contains different profiles thereby bringing more than 100 of the pioneers in psychology more vividly to life. (shrink)

This book presents a series of informal biographies about major figures in the history of psychology. A unique combination of expertise and human appeal, the volume places the contributions of each pioneer in a new and fascinating perspective. For instance, several of the authors use the novel approach of having the pioneers return to the present day to reflect back on their work as it relates to the here and now. Revisions of speeches given in a popular series of invited (...) addresses at psychological conventions, the chapters offer appealing glimpses into the lives of individuals who made a difference in the early years of psychology as a field of study. Each of the five volumes in this series contains different profiles thereby bringing more than 100 of the pioneers in psychology more vividly to life. (shrink)

This fourth book in the series continues the tradition of the popular earlier volumes by offering lively and entertaining information about some of contemporary psychology's most illustrious ancestors. The 21 chapters, many of them written by today's most visible and eminent authors, concentrate on the lives and achievements of major psychologists from a variety of areas. Created for undergraduate and graduate courses in the history of psychology, the variety of pioneers represented provide enough flexibility to also use it as a (...) supplemental reader in other psychology courses. Each of the five volumes in this series contains different profiles thereby bringing more than 100 of the pioneers in psychology more vividly to life. (shrink)

This book offers glimpses into the personal and scholarly lives of 20 giants in the history of psychology. As in the earlier volumes, prominent scholars were invited to prepare chapters on a pioneer who had made important contributions in their own area of expertise. Some of the psychologists described may be the teachers of the instructors who will be the users of this book, potentially providing a personal connection of the pioneers to the students. A special section provides brief portraits (...) of the editors and authors, containing interesting information about the relationship between the pioneers and the psychologists who describe them. Utilizing an informal, personal, sometimes humorous, style of writing, the book will appeal to students and instructors interested in the history of psychology. Each of the five volumes in this series contains different profiles thereby bringing more than 100 of the pioneers in psychology more vividly to life. (shrink)

Jesus instructs us to “love,” “pray for,” and “do good” to enemies, going so far as to make this response to enemies the criterion for being considered “children of your Father in heaven”. Jesus based this instruction on the character of the Father, not on the character of our enemies, which means his instruction allows for no exceptions. In this essay I flesh out the implications of this for a Christian response to terrorism, arguing that this response should look radically (...) different from that of just war theorists. (shrink)